Detalhe da pesquisa
1.
Accurate prediction of dynamic protein-ligand binding using P-score ranking.
J Comput Chem
; 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647338
2.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
3.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
4.
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.
Antimicrob Agents Chemother
; 66(1): e0153521, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606338
5.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
6.
Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method.
J Comput Aided Mol Des
; 35(10): 1025-1036, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458939
7.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
8.
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.
Proc Natl Acad Sci U S A
; 115(38): 9616-9621, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185555
9.
On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin.
Chemistry
; 24(54): 14448-14460, 2018 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29975429
10.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
11.
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
Bioorg Med Chem
; 22(15): 4135-50, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980703
12.
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments.
ChemMedChem
; : e202400025, 2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38581280
13.
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).
Bioorg Med Chem
; 21(22): 7047-63, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100158
14.
SophosQM: Accurate Binding Affinity Prediction in Compound Optimization.
ACS Omega
; 8(17): 15083-15098, 2023 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37151542
15.
Design and Synthesis of Covalent Inhibitors of FabA.
ACS Omega
; 8(14): 12787-12804, 2023 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37065080
16.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
J Med Chem
; 66(22): 15380-15408, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948640
17.
Short-course combination treatment for experimental chronic Chagas disease.
Sci Transl Med
; 15(726): eadg8105, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091410
18.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Sci Transl Med
; 15(726): eadh9902, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091406
19.
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
J Med Chem
; 66(15): 10413-10431, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506194
20.
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
J Med Chem
; 65(7): 5606-5624, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35303411